IgG from myeloperoxidase-antineutrophil cytoplasmic antibody-positive patients stimulates greater activation of primed neutrophils than IgG from proteinase 3-antineutrophil cytoplasmic antibody-positive patients

2001 ◽  
Vol 44 (4) ◽  
pp. 921-930 ◽  
Author(s):  
L. Harper ◽  
D. Radford ◽  
T. Plant ◽  
M. Drayson ◽  
D. Adu ◽  
...  
Keyword(s):  
Antineutrophil Cytoplasmic Antibody ◽  
Proteinase 3 ◽  
Myeloperoxidase Antineutrophil Cytoplasmic Antibody

scholarly journals A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Yasuyuki Nakada ◽  
Nobuo Tsuboi ◽  
Yasuto Takahashi ◽  
Hiraku Yoshida ◽  
Yoriko Hara ◽  
...  
Keyword(s):  
Renal Biopsy ◽  
Indirect Immunofluorescence ◽  
Crescentic Glomerulonephritis ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Basement Membranes ◽  
Proteinase 3 ◽  
Renal Deterioration ◽  
Membranous Glomerulopathy ◽  
Immunosorbent Assays ◽  
The Relationship

We report a case in which antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis and membranous glomerulopathy (MGN) were detected concurrently. The patient showed rapidly progressive renal deterioration. A renal biopsy showed crescentic glomerulonephritis, together with marked thickening and spike and bubbling formations in the glomerular basement membranes. Indirect immunofluorescence examination of the patient’s neutrophils showed a perinuclear pattern. Enzyme-linked immunosorbent assays revealed that the ANCA in this case did not target myeloperoxidase (MPO) or proteinase 3 (PR3) but bactericidal-/permeability-increasing protein, elastase, and lysosome. The relationship between these two etiologically distinct entities, MPO-/PR3-negative ANCA-associated glomerulonephritis and MGN, remains unclear.

scholarly journals Clinical evaluation of a capture ELISA for detection of proteinase-3 antineutrophil cytoplasmic antibody: Technical Note

1998 ◽  
Vol 53 (5) ◽  
pp. 1230-1236 ◽  
Author(s):  
Kerstin W.A. Westman ◽  
Daina Selga ◽  
Per Bygren ◽  
Mårten Segelmark ◽  
Bo Baslund ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Technical Note ◽  
Proteinase 3 ◽  
Capture Elisa

scholarly journals Infected Aortic Aneurysm Mimicking Anti-proteinase 3-Antineutrophil Cytoplasmic Antibody-associated Vasculitis

2016 ◽  
Vol 55 (23) ◽  
pp. 3465-3469
Author(s):  
Kenta Hachiya ◽  
Kazuaki Wakami ◽  
Atsuhiro Yoshida ◽  
Hisao Suda ◽  
Nobuyuki Ohte
Keyword(s):  
Aortic Aneurysm ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Proteinase 3 ◽  
Infected Aortic Aneurysm
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